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Near-infrared Fluorescent Divalent RGD Ligand for Integrin α(v)β(3)-targeted Optical Imaging

A new near-infrared fluorescent compound containing two cyclic RGD motifs, cypate-[c(RGDfK)](2) (1), was synthesized based on a carbocyanine fluorophore bearing two carboxylic acid groups (cypate) for integrin α(v)β(3)-targeting. Compared with its monovalent counterpart cypate-c(RGDfK) (2), 1 exhibi...

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Autores principales: Ye, Yunpeng, Akers, Walter, Xu, Baogang, Bloch, Sharon, Odonkor, Charles, Achilefu, Samuel
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423536/
https://ncbi.nlm.nih.gov/pubmed/22871580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.07.044
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