Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats

BACKGROUND AND PURPOSE: To evaluate the role of 2-arachidonoyl glycerol (2AG) in the regulation of nausea and vomiting using animal models of vomiting and of nausea-like behaviour (conditioned gaping). EXPERIMENTAL APPROACH: Vomiting was assessed in shrews (Suncus murinus), pretreated with JZL184, a...

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Main Authors: Sticht, Martin A, Long, Jonathan Z, Rock, Erin M, Limebeer, Cheryl L, Mechoulam, Raphael, Cravatt, Benjamin F, Parker, Linda A
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2012
Fag:
Themed Section: Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423233/
https://ncbi.nlm.nih.gov/pubmed/21470205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01407.x
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