Na(+)/Ca(2+) exchanger-1 protects against systolic failure in the Akita(ins2) model of diabetic cardiomyopathy via a CXCR4/NF-κB pathway

Diabetic cardiomyopathy is characterized, in part, by calcium handling imbalances associated with ventricular dysfunction. The cardiac Na(+)/Ca(2+) exchanger 1 (NCX1) has been implicated as a compensatory mechanism in response to reduced contractility in the heart; however, its role in diabetic card...

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Detalhes bibliográficos
Main Authors: LaRocca, Thomas J., Fabris, Frank, Chen, Jiqiu, Benhayon, Daniel, Zhang, Shihong, McCollum, LaTronya, Schecter, Alison D., Cheung, Joseph Y., Sobie, Eric A., Hajjar, Roger J., Lebeche, Djamel
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Integrative Cardiovascular Physiology and Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423163/
https://ncbi.nlm.nih.gov/pubmed/22610174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01198.2011
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