Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for Patched

The amino-terminal signaling domain of the Sonic hedgehog secreted protein (Shh-N), which derives from the Shh precursor through an autoprocessing reaction mediated by the carboxyl-terminal domain, executes multiple functions in embryonic tissue patterning, including induction of ventral and suppres...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Fuse, Naoyuki, Maiti, Tapan, Wang, Baolin, Porter, Jeffery A., Hall, Traci M. Tanaka, Leahy, Daniel J., Beachy, Philip A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Colloquium Paper
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC34231/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10500113/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.20.10992
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