The catalytic sites of 20S proteasomes and their role in subunit maturation: A mutational and crystallographic study

We present a biochemical and crystallographic characterization of active site mutants of the yeast 20S proteasome with the aim to characterize substrate cleavage specificity, subunit intermediate processing, and maturation. β1(Pre3), β2(Pup1), and β5(Pre2) are responsible for the postacidic, tryptic...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Groll, Michael, Heinemeyer, Wolfgang, Jäger, Sibylle, Ullrich, Tobias, Bochtler, Matthias, Wolf, Dieter H., Huber, Robert
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1999
Materias:	Colloquium Paper
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC34229/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10500111/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.20.10976
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