The catalytic sites of 20S proteasomes and their role in subunit maturation: A mutational and crystallographic study

We present a biochemical and crystallographic characterization of active site mutants of the yeast 20S proteasome with the aim to characterize substrate cleavage specificity, subunit intermediate processing, and maturation. β1(Pre3), β2(Pup1), and β5(Pre2) are responsible for the postacidic, tryptic...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Groll, Michael, Heinemeyer, Wolfgang, Jäger, Sibylle, Ullrich, Tobias, Bochtler, Matthias, Wolf, Dieter H., Huber, Robert
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Colloquium Paper
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC34229/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10500111/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.20.10976
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