Neurosteroid Analog Photolabeling of a Site in the Third Transmembrane Domain of the β3 Subunit of the GABA(A) Receptor

Accumulated evidence suggests that neurosteroids modulate GABA(A) receptors through binding interactions with transmembrane domains. To identify these neurosteroid binding sites directly, a neurosteroid-analog photolabeling reagent, (3α,5β)-6-azi-pregnanolone (6-AziP), was used to photolabel membran...

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Detalhes bibliográficos
Main Authors: Chen, Zi-Wei, Manion, Brad, Townsend, R. Reid, Reichert, David E., Covey, Douglas F., Steinbach, Joe Henry, Sieghart, Werner, Fuchs, Karoline, Evers, Alex S.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422701/
https://ncbi.nlm.nih.gov/pubmed/22648971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.078410
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