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Broad HIV-1 Neutralizing Antibody Response Induced by Heterologous Gp140/Gp145 DNA Prime-Vaccinia Boost Immunization
OBJECTIVE: To develop an effective HIV vaccine strategy that can induce cross-reactive neutralizing antibody. METHODS: Codon-optimized gp140 and gp145 env genes derived from HIV-1(cn54), a CRF07 B′/C recombinant strain, were constructed as DNA and recombinant Tiantan vaccinia (rTV) vaccines. The eff...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3422682/ https://ncbi.nlm.nih.gov/pubmed/22561314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2012.04.075 |
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