Broad HIV-1 Neutralizing Antibody Response Induced by Heterologous Gp140/Gp145 DNA Prime-Vaccinia Boost Immunization

OBJECTIVE: To develop an effective HIV vaccine strategy that can induce cross-reactive neutralizing antibody. METHODS: Codon-optimized gp140 and gp145 env genes derived from HIV-1(cn54), a CRF07 B′/C recombinant strain, were constructed as DNA and recombinant Tiantan vaccinia (rTV) vaccines. The eff...

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Main Authors: Liu, Lianxing, Hao, Yanling, Luo, Zhenwu, Huang, Yang, Hu, Xintao, Liu, Ying, Shao, Yiming
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422682/
https://ncbi.nlm.nih.gov/pubmed/22561314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2012.04.075
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