Safety and Efficacy of Combination Immunotherapy With Interferon Alfa-2b and Tremelimumab in Patients With Stage IV Melanoma

PURPOSE: We tested the hypothesis that the combination of tremelimumab and interferon alfa-2b acting via different and possibly synergistic mechanisms would overcome tumor immune tolerance and lead to significant and durable clinical responses. PATIENTS AND METHODS: We conducted a phase II study in...

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Detalhes bibliográficos
Main Authors: Tarhini, Ahmad A., Cherian, John, Moschos, Stergios J., Tawbi, Hussein A., Shuai, Yongli, Gooding, William E., Sander, Cindy, Kirkwood, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2012
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422533/
https://ncbi.nlm.nih.gov/pubmed/22184371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2011.37.5394
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