Intestinal Transport of Aminopterin Enantiomers in Dogs and Humans with Psoriasis Is Stereoselective: Evidence for a Mechanism Involving the Proton-Coupled Folate Transporter

N-[4-[[(2,4-diamino-6-pterdinyl)methyl]amino]benzoyl]-l/d-glutamic acid (l/d-AMT) is an investigational drug in phase 1 clinical development that consists of the l-and d-enantiomers of aminopterin (AMT). l/d-AMT is obtained from a novel process for making the l-enantiomer (l-AMT), a potent oral anti...

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Detalhes bibliográficos
Main Authors: Menter, Alan, Thrash, Breck, Cherian, Christina, Matherly, Larry H., Wang, Lei, Gangjee, Aleem, Morgan, Joel R., Maeda, Dean Y., Schuler, Aaron D., Kahn, Stuart J., Zebala, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
Assuntos:
Metabolism, Transport, and Pharmacogenomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422524/
https://ncbi.nlm.nih.gov/pubmed/22653877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.195479
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