Neurogenesis-Independent Antidepressant-Like Effects on Behavior and Stress Axis Response of a Dual Orexin Receptor Antagonist in a Rodent Model of Depression

Growing evidence indicates that an increase of orexin (or hypocretin) signaling is involved in the pathophysiology of major depression, but little is known regarding the causal link between the orexinergic system and depressive-like states. Here we blocked orexin receptors in mice subjected to unpre...

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Bibliografiske detaljer
Main Authors: Nollet, Mathieu, Gaillard, Philippe, Tanti, Arnaud, Girault, Virginie, Belzung, Catherine, Leman, Samuel
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422486/
https://ncbi.nlm.nih.gov/pubmed/22713907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2012.70
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