Neurogenesis-Independent Antidepressant-Like Effects on Behavior and Stress Axis Response of a Dual Orexin Receptor Antagonist in a Rodent Model of Depression

Growing evidence indicates that an increase of orexin (or hypocretin) signaling is involved in the pathophysiology of major depression, but little is known regarding the causal link between the orexinergic system and depressive-like states. Here we blocked orexin receptors in mice subjected to unpre...

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Autores principales: Nollet, Mathieu, Gaillard, Philippe, Tanti, Arnaud, Girault, Virginie, Belzung, Catherine, Leman, Samuel
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422486/
https://ncbi.nlm.nih.gov/pubmed/22713907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2012.70
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