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Novel Somatic Mutations to PI3K Pathway Genes in Metastatic Melanoma

BACKGROUND: BRAF(V600) inhibitors have offered a new gateway for better treatment of metastatic melanoma. However, the overall efficacy of BRAF(V600) inhibitors has been lower than expected in clinical trials, and many patients have shown resistance to the drug’s effect. We hypothesized that somatic...

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Hlavní autoři: Shull, Austin Y., Latham-Schwark, Alicia, Ramasamy, Poornema, Leskoske, Kristin, Oroian, Dora, Birtwistle, Marc R., Buckhaults, Phillip J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422312/
https://ncbi.nlm.nih.gov/pubmed/22912864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043369
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