The small GTPase ARF6 activates PI3K in melanoma to induce a pro-metastatic state

Melanoma has an unusual capacity to spread in early stage disease, prompting aggressive clinical intervention in very thin primary tumors. Despite these proactive efforts, patients with low-risk, low-stage disease can still develop metastasis, indicating the presence of permissive cues for distant s...

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Publicat a:Cancer Res
Autors principals: Yoo, Jae Hyuk, Brady, Samuel W., Acosta-Alvarez, Lehi, Rogers, Aaron, Peng, Jingfu, Sorensen, Lise K., Wolff, Roger K., Mleynek, Tara, Shin, Donghan, Rich, Coulson P., Kircher, David A., Bild, Andrea, Odelberg, Shannon J., Li, Dean Y., Holmen, Sheri L., Grossmann, Allie H.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7197377/
https://ncbi.nlm.nih.gov/pubmed/31048499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-3026
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