Arachidonate 15-Lipoxygenase Type B Knockdown Leads to Reduced Lipid Accumulation and Inflammation in Atherosclerosis

Inflammation in the vascular wall is important for development of atherosclerosis. We have shown previously that arachidonate 15-lipoxygenase type B (ALOX15B) is more highly expressed in human atherosclerotic lesions than in healthy arteries. This enzyme oxidizes fatty acids to substances that promo...

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Detalhes bibliográficos
Main Authors: Magnusson, Lisa U., Lundqvist, Annika, Karlsson, Merja Nurkkala, Skålén, Kristina, Levin, Max, Wiklund, Olov, Borén, Jan, Hultén, Lillemor Mattsson
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422220/
https://ncbi.nlm.nih.gov/pubmed/22912809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043142
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