Oxidative Processing of Latent Fas in the Endoplasmic Reticulum Controls the Strength of Apoptosis

We recently demonstrated that S-glutathionylation of the death receptor Fas (Fas-SSG) amplifies apoptosis (V. Anathy et al., J. Cell Biol. 184:241–252, 2009). In the present study, we demonstrate that distinct pools of Fas exist in cells. Upon ligation of surface Fas, a separate pool of latent Fas i...

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Autors principals: Anathy, Vikas, Roberson, Elle, Cunniff, Brian, Nolin, James D., Hoffman, Sidra, Spiess, Page, Guala, Amy S., Lahue, Karolyn G., Goldman, Dylan, Flemer, Stevenson, van der Vliet, Albert, Heintz, Nicholas H., Budd, Ralph C., Tew, Kenneth D., Janssen-Heininger, Yvonne M. W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422013/
https://ncbi.nlm.nih.gov/pubmed/22751926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00125-12
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