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Synthesis, DNA-binding and biological activity of a double intercalating analog of ethidium bromide.

A bis-phenanthridinium salt has been synthesized and its DNA-binding studied. Evidence provided by UV and CD spectra, by thermal denaturation profiles and by equilibrium dialysis of the drug-DNA complex lead to the conclusion that both phenanthridine moieties intercalate in the helix. The double int...

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Bibliographic Details
Main Authors: Kuhlmann, K F, Charbeneau, N J, Mosher, C W
Format: Artigo
Language:Inglês
Published: 1978
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC342191/
https://ncbi.nlm.nih.gov/pubmed/673863
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