Synthesis, DNA-binding and biological activity of a double intercalating analog of ethidium bromide.
A bis-phenanthridinium salt has been synthesized and its DNA-binding studied. Evidence provided by UV and CD spectra, by thermal denaturation profiles and by equilibrium dialysis of the drug-DNA complex lead to the conclusion that both phenanthridine moieties intercalate in the helix. The double int...
Spremljeno u:
| Izdano u: | Nucleic Acids Res |
|---|---|
| Glavni autori: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
1978
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| Online pristup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC342191/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/673863/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/5.7.2629 |
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