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Synthesis, DNA-binding and biological activity of a double intercalating analog of ethidium bromide.
A bis-phenanthridinium salt has been synthesized and its DNA-binding studied. Evidence provided by UV and CD spectra, by thermal denaturation profiles and by equilibrium dialysis of the drug-DNA complex lead to the conclusion that both phenanthridine moieties intercalate in the helix. The double int...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
1978
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| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC342191/ https://ncbi.nlm.nih.gov/pubmed/673863 |
| タグ: |
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