5S Clavam Biosynthesis Is Controlled by an Atypical Two-Component Regulatory System in Streptomyces clavuligerus

Streptomyces clavuligerus produces a collection of five clavam metabolites, including the clinically important β-lactamase inhibitor clavulanic acid, as well as four structurally related metabolites called 5S clavams. The paralogue gene cluster of S. clavuligerus is one of three clusters of genes fo...

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Hlavní autoři: Kwong, Thomas, Zelyas, Nathan J., Cai, Hui, Tahlan, Kapil, Wong, Annie, Jensen, Susan E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
Chemistry; Biosynthesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421899/
https://ncbi.nlm.nih.gov/pubmed/22751548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01090-12
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