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Pharmacological Characterization, Structural Studies, and In Vivo Activities of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib

Chagas disease, caused by the protozoan pathogen Trypanosoma cruzi, remains a challenging infection due to the unavailability of safe and efficacious drugs. Inhibitors of the trypanosome sterol 14α-demethylase enzyme (CYP51), including azole antifungal drugs, are promising candidates for development...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Buckner, Frederick S., Bahia, Maria Terezinha, Suryadevara, Praveen Kumar, White, Karen L., Shackleford, David M., Chennamaneni, Naveen Kumar, Hulverson, Matthew A., Laydbak, Joy U., Chatelain, Eric, Scandale, Ivan, Verlinde, Christophe L. M. J., Charman, Susan A., Lepesheva, Galina I., Gelb, Michael H.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Microbiology 2012
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421879/
https://ncbi.nlm.nih.gov/pubmed/22777048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06244-11
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