Safety, Tolerability, and Pharmacokinetics of Intravenous Oseltamivir: Single- and Multiple-Dose Phase I Studies with Healthy Volunteers

There is an unmet need for an intravenous (i.v.) neuraminidase inhibitor, particularly for patients with severe influenza who cannot take oral medication. Two phase I pharmacokinetic and safety studies of i.v. oseltamivir were carried out in healthy volunteers. The first was an open-label, randomize...

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Bibliografiske detaljer
Main Authors: Brennan, Barbara J., Davies, Brian, Cirrincione-Dall, Georgina, Morcos, Peter N., Beryozkina, Anna, Chappey, Colombe, Aceves Baldó, Pau, Lennon-Chrimes, Sian, Rayner, Craig R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421873/
https://ncbi.nlm.nih.gov/pubmed/22733065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00200-12
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