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Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon by Binding to MAVS and Decreasing Mitochondrial Membrane Potential

PB1-F2 is a small, 87- to 90-amino-acid-long protein encoded by the +1 alternate open reading frame of the PB1 gene of most influenza A virus strains. It has been shown to contribute to viral pathogenicity in a host- and strain-dependent manner, and we have previously discovered that a serine at pos...

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Autors principals: Varga, Zsuzsanna T., Grant, Alesha, Manicassamy, Balaji, Palese, Peter
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421771/
https://ncbi.nlm.nih.gov/pubmed/22674996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01122-12
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