Inhibiting Early-Stage Events in HIV-1 Replication by Small-Molecule Targeting of the HIV-1 Capsid

The HIV-1 capsid (CA) protein plays essential roles in both early and late stages of virl replication and has emerged as a novel drug target. We report hybrid structure-based virtual screening to identify small molecules with the potential to interact with the N-terminal domain (NTD) of HIV-1 CA and...

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Autors principals: Kortagere, Sandhya, Madani, Navid, Mankowski, Marie K., Schön, Arne, Zentner, Isaac, Swaminathan, Gokul, Princiotto, Amy, Anthony, Kevin, Oza, Apara, Sierra, Luz-Jeannette, Passic, Shendra R., Wang, Xiaozhao, Jones, David M., Stavale, Eric, Krebs, Fred C., Martín-García, Julio, Freire, Ernesto, Ptak, Roger G., Sodroski, Joseph, Cocklin, Simon, Smith, Amos B.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421734/
https://ncbi.nlm.nih.gov/pubmed/22647699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05006-11
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