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A Specific Domain of the Chikungunya Virus E2 Protein Regulates Particle Formation in Human Cells: Implications for Alphavirus Vaccine Design
Virus-like particles (VLPs) can be generated from Chikungunya virus (CHIKV), but different strains yield variable quantities of particles. Here, we define the genetic basis for these differences and show that amino acid 234 in E2 substantially affects VLP production. This site is located within the...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3421714/ https://ncbi.nlm.nih.gov/pubmed/22647698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00370-12 |
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