Progressive Loss of Memory T Cell Potential and Commitment to Exhaustion during Chronic Viral Infection

T cell exhaustion and loss of memory potential occur during many chronic viral infections and cancer. We investigated when during chronic viral infection virus-specific CD8 T cells lose the potential to form memory. Virus-specific CD8 T cells from established chronic infection were unable to become...

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Bibliographic Details
Main Authors: Angelosanto, Jill M., Blackburn, Shawn D., Crawford, Alison, Wherry, E. John
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421680/
https://ncbi.nlm.nih.gov/pubmed/22623779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00889-12
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