Mapping a Neutralizing Epitope onto the Capsid of Adeno-Associated Virus Serotype 8

Adeno-associated viruses (AAVs) are small single-stranded DNA viruses that can package and deliver nongenomic DNA for therapeutic gene delivery. AAV8, a liver-tropic vector, has shown great promise for the treatment of hemophilia A and B. However, as with other AAV vectors, host anti-capsid immune r...

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Autori principali: Gurda, Brittney L., Raupp, Christina, Popa-Wagner, Ruth, Naumer, Matthias, Olson, Norman H., Ng, Robert, McKenna, Robert, Baker, Timothy S., Kleinschmidt, Jürgen A., Agbandje-McKenna, Mavis
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Structure and Assembly
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421660/
https://ncbi.nlm.nih.gov/pubmed/22593150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00218-12
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