Amixicile, a Novel Inhibitor of Pyruvate:Ferredoxin Oxidoreductase, Shows Efficacy against Clostridium difficile in a Mouse Infection Model

Clostridium difficile infection (CDI) is a serious diarrheal disease that often develops following prior antibiotic usage. One of the major problems with current therapies (oral vancomycin and metronidazole) is the high rate of recurrence. Nitazoxanide (NTZ), an inhibitor of pyruvate:ferredoxin oxid...

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Detalhes bibliográficos
Main Authors: Warren, Cirle A., van Opstal, Edward, Ballard, T. Eric, Kennedy, Andrew, Wang, Xia, Riggins, Mary, Olekhnovich, Igor, Warthan, Michelle, Kolling, Glynis L., Guerrant, Richard L., Macdonald, Timothy L., Hoffman, Paul S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421617/
https://ncbi.nlm.nih.gov/pubmed/22585229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00360-12
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