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Checkpoint kinase 2 (Chk2) inhibits the activity of the Cdc45/MCM2-7/GINS (CMG) replicative helicase complex

The replication of eukaryote chromosomes slows down when DNA is damaged and the proteins that work at the fork (the replisome) are known targets for the signaling pathways that mediate such responses critical for accurate genomic inheritance. However, the molecular mechanisms and details of how this...

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Bibliografiske detaljer
Main Authors: Ilves, Ivar, Tamberg, Nele, Botchan, Michael R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421224/
https://ncbi.nlm.nih.gov/pubmed/22853956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211525109
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