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Molecular basis for the action of the collagen-specific chaperone Hsp47/SERPINH1 and its structure-specific client recognition

Collagen is the most abundant protein in animals and is a major component of the extracellular matrix in tissues such as skin and bone. A distinctive structural feature of all collagen types is a unique triple-helical structure formed by tandem repeats of the consensus sequence Xaa-Yaa-Gly, in which...

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Main Authors: Widmer, Christine, Gebauer, Jan M., Brunstein, Elena, Rosenbaum, Sabrina, Zaucke, Frank, Drögemüller, Cord, Leeb, Tosso, Baumann, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421173/
https://ncbi.nlm.nih.gov/pubmed/22847422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1208072109
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