Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) induces cancer cell senescence by interacting with telomerase RNA component

Oxidative stress regulates telomere homeostasis and cellular aging by unclear mechanisms. Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is a key mediator of many oxidative stress responses, involving GAPDH nuclear translocation and induction of cell death. We report here that GAPDH interacts with...

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Detalhes bibliográficos
Main Authors: Nicholls, Craig, Pinto, Alexander Ruvantha, Li, He, Li, Ling, Wang, Lihui, Simpson, Richard, Liu, Jun-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421169/
https://ncbi.nlm.nih.gov/pubmed/22847419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206672109
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