Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8(+) T cell

During the primary response, the commitment of the CD8(+) T cell to Blimp-1 expression and the terminal differentiation that Blimp-1 induces must be timed so as not to impair the process of clonal expansion. We determined whether the Hippo pathway, which links cell–cell contact to differentiation in...

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Bibliografiske detaljer
Main Authors: Thaventhiran, James E. D., Hoffmann, Anja, Magiera, Lukasz, de la Roche, Maike, Lingel, Holger, Brunner-Weinzierl, Monika, Fearon, Douglas T.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421161/
https://ncbi.nlm.nih.gov/pubmed/22745171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209115109
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