Neuropilin-1 stimulates tumor growth by increasing fibronectin fibril assembly in the tumor microenvironment

The tumor microenvironment, including stromal myofibroblasts and associated matrix proteins, regulates cancer cell invasion and proliferation. Here we report that neuropilin-1 (NRP-1) orchestrates communications between myofibroblasts and soluble fibronectin (FN) that promote α5β1 integrin-dependent...

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Detalhes bibliográficos
Main Authors: Yaqoob, Usman, Cao, Sheng, Shergill, Uday, Jagavelu, Kumaravelu, Geng, Zhimin, Yin, Meng, de Assuncao, Thiago M, Cao, Ying, Szabolcs, Anna, Thorgeirsson, Snorri, Schwartz, Martin, Yang, Ju Dong, Ehman, Richard, Roberts, Lewis, Mukhopadhyay, Debabrata, Shah, Vijay H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421041/
https://ncbi.nlm.nih.gov/pubmed/22738912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-3907
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