Neuropilin-1 stimulates tumor growth by increasing fibronectin fibril assembly in the tumor microenvironment

The tumor microenvironment, including stromal myofibroblasts and associated matrix proteins, regulates cancer cell invasion and proliferation. Here we report that neuropilin-1 (NRP-1) orchestrates communications between myofibroblasts and soluble fibronectin (FN) that promote α5β1 integrin-dependent...

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Hauptverfasser: Yaqoob, Usman, Cao, Sheng, Shergill, Uday, Jagavelu, Kumaravelu, Geng, Zhimin, Yin, Meng, de Assuncao, Thiago M, Cao, Ying, Szabolcs, Anna, Thorgeirsson, Snorri, Schwartz, Martin, Yang, Ju Dong, Ehman, Richard, Roberts, Lewis, Mukhopadhyay, Debabrata, Shah, Vijay H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421041/
https://ncbi.nlm.nih.gov/pubmed/22738912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-3907
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