Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-β signaling in hepatic stellate cells

PDGF-dependent hepatic stellate cell (HSC) recruitment is an essential step in liver fibrosis and the sinusoidal vascular changes that accompany this process. However, the mechanisms that regulate PDGF signaling remain incompletely defined. Here, we found that in two rat models of liver fibrosis, th...

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Detaylı Bibliyografya
Asıl Yazarlar: Cao, Sheng, Yaqoob, Usman, Das, Amitava, Shergill, Uday, Jagavelu, Kumaravelu, Huebert, Robert C., Routray, Chittaranjan, Abdelmoneim, Soha, Vasdev, Meher, Leof, Edward, Charlton, Michael, Watts, Ryan J., Mukhopadhyay, Debabrata, Shah, Vijay H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2010
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898590/
https://ncbi.nlm.nih.gov/pubmed/20577048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41203
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