Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-β signaling in hepatic stellate cells

PDGF-dependent hepatic stellate cell (HSC) recruitment is an essential step in liver fibrosis and the sinusoidal vascular changes that accompany this process. However, the mechanisms that regulate PDGF signaling remain incompletely defined. Here, we found that in two rat models of liver fibrosis, th...

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Detalhes bibliográficos
Main Authors: Cao, Sheng, Yaqoob, Usman, Das, Amitava, Shergill, Uday, Jagavelu, Kumaravelu, Huebert, Robert C., Routray, Chittaranjan, Abdelmoneim, Soha, Vasdev, Meher, Leof, Edward, Charlton, Michael, Watts, Ryan J., Mukhopadhyay, Debabrata, Shah, Vijay H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898590/
https://ncbi.nlm.nih.gov/pubmed/20577048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41203
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