Identification of Human Proteins That Modify Misfolding and Proteotoxicity of Pathogenic Ataxin-1

Proteins with long, pathogenic polyglutamine (polyQ) sequences have an enhanced propensity to spontaneously misfold and self-assemble into insoluble protein aggregates. Here, we have identified 21 human proteins that influence polyQ-induced ataxin-1 misfolding and proteotoxicity in cell model system...

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Detalhes bibliográficos
Main Authors: Petrakis, Spyros, Raskó, Tamás, Russ, Jenny, Friedrich, Ralf P., Stroedicke, Martin, Riechers, Sean-Patrick, Muehlenberg, Katja, Möller, Angeli, Reinhardt, Anita, Vinayagam, Arunachalam, Schaefer, Martin H., Boutros, Michael, Tricoire, Hervé, Andrade-Navarro, Miguel A., Wanker, Erich E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3420947/
https://ncbi.nlm.nih.gov/pubmed/22916034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002897
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