Stromal Liver Kinase B1 [STK11] Signaling Loss Induces Oviductal Adenomas and Endometrial Cancer by Activating Mammalian Target of Rapamycin Complex 1

Germline mutations of the Liver Kinase b1 (LKB1/STK11) tumor suppressor gene have been linked to Peutz-Jeghers Syndrome (PJS), an autosomal-dominant, cancer-prone disorder in which patients develop neoplasms in several organs, including the oviduct, ovary, and cervix. We have conditionally deleted L...

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Detalhes bibliográficos
Main Authors: Tanwar, Pradeep S., Kaneko-Tarui, Tomoko, Zhang, LiHua, Tanaka, Yoshihiro, Crum, Christopher P., Teixeira, Jose M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3420942/
https://ncbi.nlm.nih.gov/pubmed/22916036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002906
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