Long-term, efficient inhibition of microRNA function in mice using rAAV vectors

Understanding the function of individual microRNA (miRNA) species in mice would require the production of hundreds of loss-of-function strains. To accelerate analysis of miRNA biology in mammals, we combined recombinant adeno-associated virus (rAAV) vectors with miRNA `Tough Decoys' (TuDs) to i...

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Detalhes bibliográficos
Main Authors: Xie, Jun, Ameres, Stefan L., Friedline, Randall, Hung, Jui-Hung, Zhang, Yu, Xie, Qing, Zhong, Li, Su, Qin, He, Ran, Li, Mengxin, Li, Huapeng, Mu, Xin, Zhang, Hongwei, Broderick, Jennifer A., Kim, Jason K., Weng, Zhiping, Flotte, Terence R., Zamore, Phillip D., Gao, Guangping
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3420816/
https://ncbi.nlm.nih.gov/pubmed/22388288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1903
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