Thymocytes may persist and differentiate without any input from bone marrow progenitors

Thymus transplants can correct deficiencies of the thymus epithelium caused by the complete DiGeorge syndrome or FOXN1 mutations. However, thymus transplants were never used to correct T cell–intrinsic deficiencies because it is generally believed that thymocytes have short intrinsic lifespans. This...

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Autori principali: Peaudecerf, Laetitia, Lemos, Sara, Galgano, Alessia, Krenn, Gerald, Vasseur, Florence, Di Santo, James P., Ezine, Sophie, Rocha, Benedita
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2012
Soggetti:
Brief Definitive Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3420331/
https://ncbi.nlm.nih.gov/pubmed/22778388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20120845
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