Thymocytes may persist and differentiate without any input from bone marrow progenitors

Thymus transplants can correct deficiencies of the thymus epithelium caused by the complete DiGeorge syndrome or FOXN1 mutations. However, thymus transplants were never used to correct T cell–intrinsic deficiencies because it is generally believed that thymocytes have short intrinsic lifespans. This...

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Detalhes bibliográficos
Main Authors: Peaudecerf, Laetitia, Lemos, Sara, Galgano, Alessia, Krenn, Gerald, Vasseur, Florence, Di Santo, James P., Ezine, Sophie, Rocha, Benedita
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3420331/
https://ncbi.nlm.nih.gov/pubmed/22778388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20120845
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