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Nucleic acid scavengers inhibit thrombosis without increasing bleeding

Development of effective, yet safe, antithrombotic agents has been challenging because such agents increase the propensity of patients to bleed. Recently, naturally occurring polyphosphates such as extracellular DNA, RNA, and inorganic polyphosphates have been shown to activate blood coagulation. In...

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Autores principales: Jain, Shashank, Pitoc, George A., Holl, Eda K., Zhang, Ying, Borst, Luke, Leong, Kam W., Lee, Jaewoo, Sullenger, Bruce A.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3420207/
https://ncbi.nlm.nih.gov/pubmed/22837404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204928109
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