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Nucleic acid scavengers inhibit thrombosis without increasing bleeding

Development of effective, yet safe, antithrombotic agents has been challenging because such agents increase the propensity of patients to bleed. Recently, naturally occurring polyphosphates such as extracellular DNA, RNA, and inorganic polyphosphates have been shown to activate blood coagulation. In...

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Detalhes bibliográficos
Main Authors: Jain, Shashank, Pitoc, George A., Holl, Eda K., Zhang, Ying, Borst, Luke, Leong, Kam W., Lee, Jaewoo, Sullenger, Bruce A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3420207/
https://ncbi.nlm.nih.gov/pubmed/22837404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204928109
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