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Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions

In rodent sensory neurons, acid-sensing ion channel 3 (ASIC3) has recently emerged as a particularly important sensor of nonadaptive pain associated with tissue acidosis. However, little is known about the human ASIC3 channel, which includes three splice variants differing in their C-terminal domain...

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Opis bibliograficzny
Główni autorzy: Delaunay, Anne, Gasull, Xavier, Salinas, Miguel, Noël, Jacques, Friend, Valérie, Lingueglia, Eric, Deval, Emmanuel
Format: Artigo
Język:Inglês
Wydane: National Academy of Sciences 2012
Hasła przedmiotowe:
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3420194/
https://ncbi.nlm.nih.gov/pubmed/22829666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120350109
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