Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite

Through rapid genetic adaptation and natural selection, the Plasmodium falciparum parasite—the deadliest of those that cause malaria—is able to develop resistance to antimalarial drugs, thwarting present efforts to control it. Genome-wide association studies (GWAS) provide a critical hypothesis-gene...

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Hlavní autoři: Park, Daniel J., Lukens, Amanda K., Neafsey, Daniel E., Schaffner, Stephen F., Chang, Hsiao-Han, Valim, Clarissa, Ribacke, Ulf, Van Tyne, Daria, Galinsky, Kevin, Galligan, Meghan, Becker, Justin S., Ndiaye, Daouda, Mboup, Souleymane, Wiegand, Roger C., Hartl, Daniel L., Sabeti, Pardis C., Wirth, Dyann F., Volkman, Sarah K.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3420184/
https://ncbi.nlm.nih.gov/pubmed/22826220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210585109
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