Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding

The t(8;21) translocation fuses the DNA-binding domain of the hematopoietic master regulator RUNX1 to the ETO protein. The resultant RUNX1/ETO fusion protein is a leukemia-initiating transcription factor that interferes with RUNX1 function. The result of this interference is a block in differentiati...

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Bibliographische Detailangaben
Hauptverfasser: Ptasinska, A, Assi, S A, Mannari, D, James, S R, Williamson, D, Dunne, J, Hoogenkamp, M, Wu, M, Care, M, McNeill, H, Cauchy, P, Cullen, M, Tooze, R M, Tenen, D G, Young, B D, Cockerill, P N, Westhead, D R, Heidenreich, O, Bonifer, C
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419980/
https://ncbi.nlm.nih.gov/pubmed/22343733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2012.49
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