A novel mechanism for ERK-dependent regulation of IL4 transcription during human Th2-cell differentiation

We demonstrate that the mitogen-activated protein kinases extracellular signal-regulated kinase (ERK)-1 and ERK-2 have a central role in mediating T-cell receptor-dependent induction of IL4 expression in human CD4(+) T cells. Significantly, this involved a novel mechanism wherein receptor cross-link...

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Библиографические подробности
Главные авторы: Tripathi, Parul, Sahoo, Naresh, Ullah, Ubaid, Kallionpää, Henna, Suneja, Amita, Lahesmaa, Riitta, Rao, Kanury V S
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2012
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419974/
https://ncbi.nlm.nih.gov/pubmed/21989417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2011.87
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