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A novel mechanism for ERK-dependent regulation of IL4 transcription during human Th2-cell differentiation
We demonstrate that the mitogen-activated protein kinases extracellular signal-regulated kinase (ERK)-1 and ERK-2 have a central role in mediating T-cell receptor-dependent induction of IL4 expression in human CD4(+) T cells. Significantly, this involved a novel mechanism wherein receptor cross-link...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3419974/ https://ncbi.nlm.nih.gov/pubmed/21989417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2011.87 |
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