Role of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia and airway mucus formation in vitro and in vivo

BACKGROUND: Airway mucus hypersecretion is a key pathophysiological feature in number of lung diseases. Cigarette smoke/nicotine and allergens are strong stimulators of airway mucus; however, the mechanism of mucus modulation is unclear. OBJECTIVES: Characterize the pathway by which cigarette smoke/...

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Autors principals: Gundavarapu, Sravanthi, Wilder, Julie A., Mishra, Neerad C., Rir-sima-ah, Jules, Langley, Raymond J., Singh, Shashi P., Saeed, Ali Imran, Jaramillo, Richard J., Gott, Katherine M., Peña-Philippides, Juan Carlos, Harrod, Kevin S., McIntosh, J. Michael, Buch, Shilpa, Sopori, Mohan L.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419772/
https://ncbi.nlm.nih.gov/pubmed/22578901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2012.04.002
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