Cardiomyocyte-Specific Expression of Lamin A Improves Cardiac Function in Lmna (−/−) Mice

Lmna (−/−) mice display multiple tissue defects and die by 6–8 weeks of age reportedly from dilated cardiomyopathy with associated conduction defects. We sought to determine whether restoration of lamin A in cardiomyocytes improves cardiac function and extends the survival of Lmna (−/−) mice. We obs...

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Main Authors: Frock, Richard L., Chen, Steven C., Da, Dao-Fu, Frett, Ellie, Lau, Carmen, Brown, Christina, Pak, Diana N., Wang, Yuexia, Muchir, Antoine, Worman, Howard J., Santana, Luis F., Ladiges, Warren C., Rabinovitch, Peter S., Kennedy, Brian K.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419749/
https://ncbi.nlm.nih.gov/pubmed/22905185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042918
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