Genotyping of a tri-allelic polymorphism by a novel melting curve assay in MTHFD1L: an association study of nonsyndromic Cleft in Ireland

BACKGROUND: Polymorphisms within the MTHFD1L gene were previously associated with risk of neural tube defects in Ireland. We sought to test the most significant MTHFD1L polymorphisms for an association with risk of cleft in an Irish cohort. This required the development of a new melting curve assay...

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Bibliographic Details
Main Authors: Minguzzi, Stefano, Molloy, Anne M, Peadar, Kirke, Mills, James, Scott, John M, Troendle, James, Pangilinan, Faith, Brody, Lawrence, Parle-McDermott, Anne
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
Subjects:
Technical Advance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419639/
https://ncbi.nlm.nih.gov/pubmed/22520921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-13-29
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