Genotyping of a tri-allelic polymorphism by a novel melting curve assay in MTHFD1L: an association study of nonsyndromic Cleft in Ireland

BACKGROUND: Polymorphisms within the MTHFD1L gene were previously associated with risk of neural tube defects in Ireland. We sought to test the most significant MTHFD1L polymorphisms for an association with risk of cleft in an Irish cohort. This required the development of a new melting curve assay...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Minguzzi, Stefano, Molloy, Anne M, Peadar, Kirke, Mills, James, Scott, John M, Troendle, James, Pangilinan, Faith, Brody, Lawrence, Parle-McDermott, Anne
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2012
Gaiak:
Technical Advance
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419639/
https://ncbi.nlm.nih.gov/pubmed/22520921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-13-29
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